英语翻译PreincubationofSLKcellswithfreecRGDpeptidesignificantlyreducedthecytotoxicresponseofSLKcellsto16%cRGD-DOXO-SPIOmicelles(PG:67.1±5.0%),supportingtheX-dependentgrowthinhibition.Inthecurrentmicelledesign,encapsulatio

Question

英语翻译
Preincubation of SLK cells with free cRGD peptide significantly
reduced the cytotoxic response of SLK cells to 16%
cRGD-DOXO-SPIO micelles (PG:67.1±5.0%),supporting
the X-dependent growth inhibition.In the current micelle
design,encapsulation of DOXO and SPIO nanoparticles
inside the hydrophobic micelle cores has the advantages of
avoiding potential exposure of hydrophobic SPIO surfaces
and adsorption of blood proteins.In addition,polymer chain
entanglement led to a very low critical micelle concentration
(CMC) at 12 ug/mL.All of the experiments in the current
study were performed at concentrations much higher than
the CMC to ensure the integrity of micelles.“Stealth”
micelles with similar PEG-PLA copolymer compositions
have demonstrated significantly increased in vivo half-lives
of drugs (e.g.,paclitaxel) to 11 h in cancer patients.The
increased in vivo stability should enhance the effectiveness
of these cRGD-functionalized micelles for active targeting
to tumor vasculature.Current work is in progress to evaluate
the in vivo efficacy of the cRGD-DOXO-SPIO micelles in
an animal tumor model.

Answer 1

SLK 细胞的预孵化与自由RGD 肽极大使SLK 细胞降低细胞毒素的反应到16% RGD-DOXO-SPIO 胶束(页:67.1.5.0%),支持 X 依赖成长禁止.在当前的胶束设计,DOXO 和SPIO 的封闭在疏水胶束里面核心有好处避免疏水SPIO 表面潜在的曝光并且血液蛋白质的吸附.另外,聚合物链子缠结导致了非常低重要胶束集中 (CMC) 在..12 ug/mL .所有实验在潮流研究更加高级被进行了以集中比 CMC 保证胶束正直 .胶束以相似的PEG-PLA 共聚物构成展示了显著增加的活体内半衰期药物到11 h 在癌症病人.它增加的活体内稳定应该提高有效率这些RGD- 胶束为活跃瞄准对肿瘤脉管系统 .当前的工作是进展中评估 RGD-DOXO-SPIO 胶束的活体内效力动物肿瘤模型.
os：有些专业的东东 比如RGD-DOXO-SPIO这样的 就不知道了